Many of the early driver mutations that are common in cancer alter both the regulation of metabolism in the cell and the epigenetic switches on DNA and histones that change differentiation states of the cell. Research into the relationship between epigenetics and cancer is important because these pathways can potentially be corrected with small molecules and dietary change. Dan's research has discovered specific metabolic vulnerabilities conferred by common mutations in blood cancers (including IDH1, IDH2, TET2 and WT1 mutations) that offer hope for developing new targeted therapies.
The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.